Efeito do uso de probióticos sobre os sintomas da depressão: revisão sistemática
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Date
2021-12-13
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Universidade Católica do Salvador
Abstract
Introduction: Considered the “evil of the century”, depression is a contemporary
phenomenon, due to the high epidemiological indices. Scientific studies demonstrate that the
use of probiotics can be beneficial in reducing depressive symptoms, as they can act on
stimuli in the brain centers that initiate behavioral responses. Objective: Systematically
review, randomized clinical studies involving probiotic supplementation and its effects on
depressive symptoms. Methodology: A systematic search in the SciELO, BVS, Pubmed and
LILACS databases was performed, resulting in the selection of 10 double and triple-blind
clinical studies, randomized and placebo-controlled on the use of probiotics as an adjuvant
treatment for depression. Data were presented in a table, containing information such as
probiotic strains, treatment duration and psychological outcome. Results: Eight articles
showed a significant beneficial effect regarding the reduction of depressive symptoms or
depression scales, with Lactobacillus and Bifidobacterium being the most used probiotic
strains. Conclusion: The use of probiotics to alleviate depressive symptoms shows promising
results, but larger and more rigorous randomized, double-blind, placebo-controlled clinical
trials are still needed to assess these conclusions.
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Keywords
Sintomas depressivos, Depressão, Probióticos, Microbioma intestinal, Depressive symptoms, Depression, Probiotics, Intestinal microbiome